New-generation 3D printed biomedical device based on micro-scale hydrodynamic cavitation

Seyedmirzaei Sarraf, Seyedali (2022) New-generation 3D printed biomedical device based on micro-scale hydrodynamic cavitation. [Thesis]

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Cavitation is a phase change phenomenon from liquid phase to vapor phase upon a sudden drop in local pressure below the saturation vapor pressure. Energy of nucleation sites is stored inside cavitation bubbles and transferred with it. The collapse of cavitation bubbles as a result of this phenomenon releases a large amount of energy and has mechanical, thermal, and chemical effects on the nearby surface. As a biomedical application, laser and acoustic induced cavitation accounting for two important types of cavitation have been extensively used for treatment of urinary tract disorders which requires ablation procedures. The complexity of such devices leads to increased final production cost of devices. On the other hand, hydrodynamic cavitation could be an inexpensive, local and energy efficient alternative and has also been previously proven through in vitro trials. In this thesis, a portable flexible cystoscopy device equipped with a hydrodynamic cavitation probe was designed, fabricated, and examined successfully in an in vivo test. The related pathology report indicated that sharply demarcated tissue defects occurred in the epithelial and subepithelial tissues in the area exposed to the hydrodynamic cavitation. As a result, a new-generation biomedical device prototype based on micro-scale hydrodynamic cavitation was designed and developed.
Item Type: Thesis
Uncontrolled Keywords: Biomedical Instrument. -- Hydrodynamic Cavitation. -- Flexible Cystoscopy Probe. -- Additive Manufacturing. -- In vivo Experiment. -- Biyomedikal Enstrüman. -- Hidrodinamik Kavitasyon. -- Esnek Sistoskopi Probu. -- Eklemeli İmalat. -- In vivo Deney.
Subjects: T Technology > TJ Mechanical engineering and machinery > TJ163.12 Mechatronics
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Mechatronics
Faculty of Engineering and Natural Sciences
Depositing User: Dila Günay
Date Deposited: 25 Jul 2023 14:50
Last Modified: 27 Nov 2023 13:47

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