Kinetic study of autophagy activation in fibroblasts interacted with single tumor cell in microfluidic platform

Official URL: http://media.wix.com/ugd/11229a_4388559236d44ac58fb0825a135f0dfc.pdf

Communication between tumor and carcinoma associated fibroblast cells (CAFs) become hot topic in cancer research recently because of their roles in tumor proliferation, metastasis and angiogenesis. Tumor cells interact with fibroblasts and make fibroblasts transdifferentiate to CAFs and autophagy in CAFs is induced. [1] To study mechanism of autophagy of CAFs by tumors, we try to develop a high throughput screening chip based on a single tumor cell-to-fibroblasts interaction. Junyoung Kim, Hacer Ezgi Karakas, Yongjun Choi, Devrim Gozuacik, Yoon-Kyoung Cho, Proceedings of Anuual Autumn Meeting of the Korean BioChip Society'15, Gangwon, Korea, pp 126, 2015