Development of microfabricated tools to investigate immune cell-tumor cell interactions

Official URL: http://dx.doi.org/10.4172/2155-9899.C1.027

Understanding the interactions between tumor cells and immune cells in a quantitative manner will provide valuable information to reveal the mechanism of diseases, immune defense and development of new treatment reagents and strategies for the diseases. Today one of the biggest limitations relies on the traditional methods and tools that we use to investigate the rare cells and speci c events in biology particularly in immunology. Since these techniques are not adequate enough to be selective, speci c and quantitative, the rare cells such as the metastatic or drug resistant ones or the events such as onset symptoms of tumors and infections are being masked by majority of the cells or events in the population. erefore, we cannot diagnosis on time or provide successful strategies. As a consequence, our approaches might not target the right cells at the right time in the right place. To overcome these limitations, we might pro t from engineering approaches and tools. We can develop quantitative, accurate, reproducible and precise methods and use microfabricated tools to understand the nature and behavior of rare cells and events. e improvements from microfabricated tools in conjunction with microscopy might provide statistics from large numbers of single cells, short assay time, less sample consumption, less waste production, quantitative and reproducible data, single-cell resolution images, high-throughput, spatio-temporal tracking and real-time assays, etc. is talk will present recently developed microfabricated tools to understand the immune cell-tumor cell interactions. I will present our micro uidic applications and their preliminary data from my research group.