Survival signals induced by low concentrations of 27-hydroxycholesterol in human monocytic cells via ERK activation

Official URL: http://dx.doi.org/10.1016/j.freeradbiomed.2012.08.489

Oxysterols are oxidized derivatives of cholesterol, most likely contributing to the development of atherosclerosis. On the basis of the clear findings by previous workers about oxysterol-mediated induction of survival pathways aside that of death pathways, we aimed to identify the main genes and related products involved in the transduction of survival signals and elucidate the relevant molecular mechanisms in human macrophagic cells challenged with 27-hydroxycholesterol in the low micromolar range.