Anatomical landmark based registration of contrast enhanced-t1 weighted magnetic resonance images

Official URL: http://192.168.1.20/record=b1304382 (Table of Contents)

In many problems involving multiple image analysis, an image registration step is required. One such problem appears in brain tumor imaging, where baseline and follow-up image volumes from a tumor patient are often to-be compared. Nature of the registration for a change detection problem in brain tumor growth analysis is mainly rigid. Contrast enhanced T1-weighted MR images (CE-T1 MRI) are widely used in clinical practice for monitoring brain tumors. Over this modality, contours of the active tumor cells and whole tumor borders and margins are visually enhanced. In this thesis, a new technique to register serial CE-T1 MRI is presented. The proposed fully-automated method is based on five anatomical landmarks: eye balls, nose, confluence of sagittal sinus, and apex of superior sagittal sinus. After extraction of anatomical landmarks from fixed and moving volumes, a rigid transformation is estimated by minimizing the sum of squared distances between the landmark coordinates. Final result is refined with a surface registration, which is based on head masks confined to the surface of the scalp, as well as to a plane constructed from three of the extracted features. The overall registration is not intensity based, and it depends only on the inherent anatomical structures. Validation studies using both synthetically transformed MRI data, and real MRI scans, which included several markers over the head of the patient were performed. In addition, comparison studies against manual landmarks marked by a radiologist, as well as against the results obtained from ITK mean squares and cross correlation based methods were carried out to demonstrate the effectiveness of the proposed method.