Nutrient limitations on photosynthesis: from individual to combinational stresses

Official URL: https://dx.doi.org/10.1016/j.tplants.2025.03.006

Liebig's law of the minimum states that increasing photosynthetic productivity on nutrient-impoverished soils depends on addressing the most limiting nutrient. Research has identified the roles of different mineral nutrients in photosynthetic processes. However, diffusional and biochemical regulation of photosynthesis both feature patterns of cumulative effects that jointly determine photosynthetic capacity. More importantly, responses to multiple nutrient stresses are not simply additive and require a comprehensive understanding of how these stresses interact and impact photosynthetic performance. In this review we highlight key macroelements for photosynthesis – nitrogen, phosphorus, potassium, and magnesium – focusing on their unique functions and interactions in regulating carbon fixation under multiple nutrient deficiencies, with the goal of enhancing crop productivity through balanced nutrient applications.