Hydrodynamic cavitation-induced thrombolysis on a clot-on-a-chip platform

Özogul, Beyzanur and Akar, Ünal and Mercimek, Rabia and Rokhsar Talabazar, Farzad and Seyedmirzaei Sarraf, Seyedali and Sheibani Aghdam, Araz and Ansari Hamedani, Ali and Villanueva, Luis Guillermo and Grishenkov, Dmitry and Amani, Ehsan and Elverdi, Tugrul and Ghorbani, Morteza and Koşar, Ali (2024) Hydrodynamic cavitation-induced thrombolysis on a clot-on-a-chip platform. Advanced NanoBiomed Research . ISSN 2699-9307 Published Online First https://dx.doi.org/10.1002/anbr.202400112

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Abstract

Complications from thrombosis constitute a massive global burden for human health. Current treatment methods have limitations and can cause serious adverse effects. Hydrodynamic cavitation (HC) is a physical phenomenon where bubbles develop and collapse rapidly within a moving liquid due to sudden pressure changes. These collapsing bubbles provide high targeted energy which can be used in a controlled environment with the help of microfluidic devices. This study introduces a new clot-on-a-chip (CoC) platform based on HC, evaluated for thrombolysis efficacy. The microfluidic device, paired with a polydimethylsiloxane (PDMS) microchip, generates cavitation bubbles at low upstream pressures (≤482 kPa), enabling microscale blood clot erosion. Different HC exposure conditions (varying pressure and duration) are assessed by changes in clot mass, diameter, and scanning electron microscopy (SEM). The largest mass reduction occurs at 482 kPa for 120 s, with a decrease of 6.1 ± 0.12 mg, while the most erosion in diameter of blood clots is obtained 482 kPa for 120 s with complete removal. SEM results show increasing damage to clot structure from less to more intense HC exposures. The CoC platform, at controlled pressures and durations, efficiently disrupts clot structure and offers a promising drug-free alternative for thrombolysis treatment.
Item Type: Article
Uncontrolled Keywords: clot-on-chips; hydrodynamic cavitations; PDMS microchips; silicon−glass microfluidic devices
Divisions: Center of Excellence on Nano Diagnostics
Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Koşar
Date Deposited: 20 Dec 2024 16:09
Last Modified: 20 Dec 2024 16:09
URI: https://research.sabanciuniv.edu/id/eprint/50544

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