A microfluidic device based on bubble generation as an organ-on-chip model

Official URL: https://www.micronanoflows.com/_files/ugd/1e39d7_4114c81b0bdb4e4caa0d27332364e445.pdf

Cavitation is a fast, energy-efficient, and emerging method for biomedical applications. With the developments in microfluidic technology, it has become easier to manipulate, visualize and analyze cavitation bubbles forming in functional microfluidic devices. In this sense, cavitation could be an alternative concept in the organ-on-chip studies. Clot or coagulation factors as the organ representative could cause dangerous and even fatal diseases in the presence of excess amount in the body. Although their treatment is usually accomplished with chemical drugs, there is a need for alternative treatment because of related side effects and inadequacies. In this study, a microfluidic system based on cavitation suitable for clot analysis is suggested to examine the clot characteristics. Our study is thus a pioneering study in the assessment of the effect of cavitation on clots.