The comparison of contribution of GO and rGO produced by green synthesis to the properties of CMC-based wound dressing material

Official URL: https://dx.doi.org/10.1016/j.ijbiomac.2024.132521

Herein, GO (graphene oxide) or rGO (reduced graphene oxide) which is produced by the green synthesis method using plant extract (Laurus nobilis) was incorporated into a polymeric structure consisting of carboxymethyl cellulose (CMC) and polyethylene glycol (PEG) to produce a wound dressing material with enhanced mechanical and electrical properties. The effect of GO and rGO on the wound dressing features of the produced materials was investigated and compared to each other. Conductivity tests demonstrated that rGO contributed more significantly to the electrical conductivity than GO. While rGO-CMC/PEG/CA reached 3.01 × 10−6 S.cm−1 as the conductivity value, that of GO-CMC/PEG/CA was determined as 0.85 × 10−6 S.cm−1. As for the mechanical tests, it was seen that rGO achieved the best results in terms of elastic modulus (588.62 N/mm2), tensile strength (94.95 MPa) and elongation at break (17.64 %) compared to GO reinforced and pure hydrogel. Curcumin and ascorbic acid were used for antibiotic-free wound treatment and their release kinetics were also modeled. The results showed that rGO reinforced hydrogel provided a more controlled release. All results assured that both the produced GO reinforced and especially rGO reinforced hydrogels could be utilized as modern wound dressing materials with suitable properties to achieve remarkable results for wound healing.