Efficient sensing of single viruses and nanoparticles by nanomechanical sensors integrated with ion lenses

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Erdogan, R. Tufan and Alkhaled, Mohammed and Kaynak, Batuhan E. and Alhmoud, Hashim and Pisheh, Hadi S. and Kelleci, Mehmet and Karakurt, Ilbey and Yanık, Cenk and Sen, Z. Betul and Yagci, A. Murat and Ozkul, Aykut and Hanay, M. Selim (2021) Efficient sensing of single viruses and nanoparticles by nanomechanical sensors integrated with ion lenses. In: 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2021), Palm Springs, Virtual, USA

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Abstract

Nanoelectromechanical Systems (NEMS) resonators can be used to detect, weigh and identify single nanoparticles and viruses. Given their small footprint, however, NEMS are plagued by low analyte detection rate since the active sensing cross-sections to capture analyte particles is very small. Here we report on the development of an on-chip focusing lens operating in air and integrated with the NEMS sensor. The integrated system increases the capture efficiency by orders of magnitude, and allows for operation under ambient conditions to measure the mass of nanoparticles and virions. With this system, mass spectrum of nanoparticle samples and mammalian viruses at biologically relevant concentrations can be characterized within less than 30 minutes.
Item Type: Papers in Conference Proceedings
Uncontrolled Keywords: Mass Spectrometry; Nanomechanical Sensors; Nanoparticle Detection; NEMS; Virus Detection
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: Cenk Yanık
Date Deposited: 21 Sep 2022 15:05
Last Modified: 21 Sep 2022 15:05
URI: https://research.sabanciuniv.edu/id/eprint/44497

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