Bone tissue engineering: anionic polysaccharides as promising scaffolds

Ponnurengam Malliappan, Sivakumar and Yetişgin, Abuzer Alp and Şahin, Sevilay Burcu and Demir, Ebru and Çetinel, Sibel (2022) Bone tissue engineering: anionic polysaccharides as promising scaffolds. Carbohydrate Polymers, 283 . ISSN 0144-8617 (Print) 1879-1344 (Online)

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Abstract

Bone repair is a self-healing process through modelling and remodeling. However, critical-sized bone defects need bone augmentation where bone tissue engineering plays vital role. Bone tissue Engineering (BTE) requires unique combinations of scaffolds, cells, and bio-signal molecules. Bone scaffold materials should be biocompatible, bioresorbable and exhibit biomimetic properties. Natural polymers, acquiring cell binding motives, producing nontoxic degradation products and tunable properties are ideal materials. Anionic polysaccharides of natural origin mimic mammalian ECM components and even the group called GAGs (Glycosaminoglycan) are actual components of ECM possessing various functions including cell adhesion, cell signaling, maintenance of homeostasis and inflammation control. Among them, anionic polysaccharides provide stabilization and sustained release of growth factors (GFs), porosity, calcium phosphate nucleation site, viscoelasticity, and water retention. Therefore, anionic polysaccharides are unique biomaterials for BTE. In this review, we have summarized the highlights of bone tissue engineering and recent applications of anionic polysaccharides in BTE.
Item Type: Article
Uncontrolled Keywords: Bone regeneration; Glycosaminoglycans; Osteogenesis
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences > Academic programs > Materials Science & Eng.
Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Sibel Çetinel
Date Deposited: 25 Aug 2022 22:11
Last Modified: 25 Aug 2022 22:11
URI: https://research.sabanciuniv.edu/id/eprint/43964

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