Mesoporous bioactive glasses in cancer diagnosis and therapy: stimuli-responsive, toxicity, immunogenicity, and clinical translation

Sharifi, Esmaeel and Bigham, Ashkan and Yousefiasl, Satar and Trovato, Maria and Ghomi, Matineh and Esmaeili, Yasaman and Samadi, Pouria and Zarrabi, Ali and Ashrafizadeh, Milad and Sharifi, Shokrollah and Sartorius, Rossella and Dabbagh Moghaddam, Farnaz and Maleki, Aziz and Song, Hao and Agarwal, Tarun and Maiti, Tapas Kumar and Nikfarjam, Nasser and Burvill, Colin and Mattoli, Virgilio and Raucci, Maria Grazia and Zheng, Kai and Boccaccini, Aldo R. and Ambrosio, Luigi and Makvandi, Pooyan (2022) Mesoporous bioactive glasses in cancer diagnosis and therapy: stimuli-responsive, toxicity, immunogenicity, and clinical translation. Advanced Science, 9 (2). ISSN 2198-3844

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Abstract

Cancer is one of the top life-threatening dangers to the human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well as diagnostics. A new system within the bioactive glass family, mesoporous bioactive glasses (MBGs), has evolved into a multifunctional platform, thanks to MBGs easy-to-functionalize nature and tailorable textural properties—surface area, pore size, and pore volume. Although MBGs have yet to meet their potential in tumor treatment and imaging in practice, recently research has shed light on the distinguished MBGs capabilities as promising theranostic systems for cancer imaging and therapy. This review presents research progress in the field of MBG applications in cancer diagnosis and therapy, including synthesis of MBGs, mechanistic overview of MBGs application in tumor diagnosis and drug monitoring, applications of MBGs in cancer therapy (particularly, targeted delivery and stimuli-responsive nanoplatforms), and immunological profile of MBG-based nanodevices in reference to the development of novel cancer therapeutics.
Item Type: Article
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 27 Aug 2022 15:39
Last Modified: 27 Aug 2022 15:39
URI: https://research.sabanciuniv.edu/id/eprint/43867

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