Ashrafizadeh, Milad and Mirzaei, Sepideh and Gholami, Mohammad Hossein and Hashemi, Farid and Zabolian, Amirhossein and Raei, Mehdi and Hushmandi, Kiavash and Zarrabi, Ali and Voelcker, Nicolas H. and Aref, Amir Reza and Hamblin, Michael R. and Varma, Rajender S. and Samarghandian, Saeed and Arostegi, I. J. and Alzola, M. and Kumar, Alan Prem and Thakur, Vijay Kumar and Nabavi, Noushin and Makvandi, Pooyan and Tay, Franklin R. and Orive, Gorka (2021) Hyaluronic acid-based nanoplatforms for Doxorubicin: a review of stimuli-responsive carriers, co-delivery and resistance suppression. Carbohydrate Polymers, 272 . ISSN 0144-8617 (Print) 1879-1344 (Online)
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Official URL: https://dx.doi.org/10.1016/j.carbpol.2021.118491
Abstract
An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor-mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CD44; Doxorubicin; Drug resistance; Endocytosis; Hyaluronic acid; Nanodelivery system; Theranostic |
| Divisions: | Faculty of Engineering and Natural Sciences Sabancı University Nanotechnology Research and Application Center |
| Depositing User: | Ali Zarrabi |
| Date Deposited: | 30 Aug 2022 12:52 |
| Last Modified: | 30 Aug 2022 12:52 |
| URI: | https://research.sabanciuniv.edu/id/eprint/43704 |
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