Production and characterization of antibiotic containing nano calcium phosphates

Bakan, Feray (2021) Production and characterization of antibiotic containing nano calcium phosphates. In: Saglam, Necdet and Korkusuz, Feza and Prasad, Ram, (eds.) Nanotechnology Applications in Health and Environmental Sciences. Nanotechnology in the Life Sciences. Springer Cham, Switzerland, pp. 299-317. ISBN 978-3-030-64412-3 (Print) 978-3-030-64410-9 (Online)

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Implant-related infections constitute a large percentage of hospital-acquired infections and may result in implant failure and bone degradation. Such occurrences stem from either the colonization of bacteria around the host tissue or the formation of biofilm on the implant surface. In clinical treatment, antibiotics may be administered systemically or locally. The latter is expected to be much more effective due to the local intensified antibacterial activity with minimal systemic toxicity. In order to achieve such an outcome, suitable carriers need to be developed. Among many biodegradable carriers, calcium phosphates have attracted specific interest owing to their osteoconductive and bioactive characteristics. This chapter aims to bring together the results reported in the current relevant literature about the applications of calcium phosphates used for local delivery of a variety of antibiotics. Specifically, the influence of the delivery system properties both on drug-releasing profile and antibacterial activity are discussed.
Item Type: Book Section / Chapter
Uncontrolled Keywords: Antibiotics; Calcium phosphate nanoparticles; Controlled drug release; Drug delivery; Hydroxyapatite
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: Feray Bakan
Date Deposited: 02 Sep 2022 12:01
Last Modified: 02 Sep 2022 12:08

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