Production and characterization of antibiotic containing nano calcium phosphates

Official URL: https://dx.doi.org/10.1007/978-3-030-64410-9_16

Implant-related infections constitute a large percentage of hospital-acquired infections and may result in implant failure and bone degradation. Such occurrences stem from either the colonization of bacteria around the host tissue or the formation of biofilm on the implant surface. In clinical treatment, antibiotics may be administered systemically or locally. The latter is expected to be much more effective due to the local intensified antibacterial activity with minimal systemic toxicity. In order to achieve such an outcome, suitable carriers need to be developed. Among many biodegradable carriers, calcium phosphates have attracted specific interest owing to their osteoconductive and bioactive characteristics. This chapter aims to bring together the results reported in the current relevant literature about the applications of calcium phosphates used for local delivery of a variety of antibiotics. Specifically, the influence of the delivery system properties both on drug-releasing profile and antibacterial activity are discussed.