Crosstalk between mammalian autophagy and the ubiquitin-proteasome system

Kocatürk, Nur Mehpare and Gözüaçık, Devrim (2018) Crosstalk between mammalian autophagy and the ubiquitin-proteasome system. Frontiers in Cell and Developmental Biology, 6 . ISSN 2296-634X

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Autophagy and the ubiquitin-proteasome system (UPS) are the two major intracellular quality control and recycling mechanisms that are responsible for cellular homeostasis in eukaryotes. Ubiquitylation is utilized as a degradation signal by both systems, yet, different mechanisms are in play. The UPS is responsible for the degradation of short-lived proteins and soluble misfolded proteins whereas autophagy eliminates long-lived proteins, insoluble protein aggregates and even whole organelles (e.g., mitochondria, peroxisomes) and intracellular parasites (e.g., bacteria). Both the UPS and selective autophagy recognize their targets through their ubiquitin tags. In addition to an indirect connection between the two systems through ubiquitylated proteins, recent data indicate the presence of connections and reciprocal regulation mechanisms between these degradation pathways. In this review, we summarize these direct and indirect interactions and crosstalks between autophagy and the UPS, and their implications for cellular stress responses and homeostasis.
Item Type: Article
Uncontrolled Keywords: autophagy; UPS; proteasome; ubiquitylation; protein quality control; mitophagy; proteostasis; organelle homeostasis
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Sabancı University Nanotechnology Research and Application Center
Faculty of Engineering and Natural Sciences
Depositing User: Devrim Gözüaçık
Date Deposited: 07 Aug 2019 20:06
Last Modified: 06 Jun 2023 14:18

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