Behavior of HepG2 liver cancer cells using microfluidic-microscopy: a preliminary study

Karamahmutoğlu, Hande and Çetin, Metin and Yağcı, Tamer and Elitaş, Meltem (2018) Behavior of HepG2 liver cancer cells using microfluidic-microscopy: a preliminary study. In: Microfluidics, BioMEMS, and Medical Microsystems XVI, San Francisco, USA

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Abstract

Hepatocellular carcinoma is one of the most common types of liver cancer causing death all over the world. Although early-stage liver cancer can sometimes be treated with partial hepatectomy, liver transplantation, ablation, and embolization, sorafenib treatment is the only approved systemic therapy for advanced HCC. The aim of this research is to develop tools and methods to understand the individuality of hepatocellular carcinoma. Microfluidic cell-culture platform has been developed to observe behavior of single-cells; fluorescence microscopy has been implemented to investigate phenotypic changes of cells. Our preliminary data proved high-level heterogeneity of hepatocellular carcinoma while verifying limited growth of liver cancer cell lines on the silicon wafer.
Item Type: Papers in Conference Proceedings
Uncontrolled Keywords: Microfluidics; HepG2; heterogeneity; microscopy; single-cell analysis; silicon wafer
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Meltem Elitaş
Date Deposited: 26 Jun 2018 11:46
Last Modified: 26 Apr 2022 09:29
URI: https://research.sabanciuniv.edu/id/eprint/34299

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