Autophagy and cancer

Karakaş, Hacer Ezgi and Gözüaçık, Devrim (2014) Autophagy and cancer. Turkish Journal of Biology, 38 (6). pp. 720-739. ISSN 1300-0152 (Print) 1303-6092 (Online)

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Autophagy is an evolutionary conserved intracellular degradation and stress response mechanism that is mainly responsible for the breakdown and recycling of cytoplasmic materials, including long-lived proteins, protein aggregates, and damaged organelles. In this way, autophagy provides the cell with building blocks and allows the maintenance of homeostasis under stress conditions such as growth factor deficiency, nutrient deprivation, hypoxia, and toxins. Consequently, abnormalities of autophagy contribute to a number of pathologies ranging from neurodegenerative diseases to cancer. Autophagy was reported to have a dual role in cancer. Depending on cancer stage, autophagy seems to act as tumor suppressor or as a mechanism supporting tumor growth and spread. In this review, we provide a summary of the relevant literature and discuss the role of autophagy in cancer formation and chemotherapy responses.
Item Type: Article
Additional Information: SCI indexed. Impact Factor 1.2
Uncontrolled Keywords: Autophagy, stress, cancer, tumor, oncogenes, tumor suppressors, metastasis, cell death, chemotherapy
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Devrim Gözüaçık
Date Deposited: 20 Dec 2014 11:29
Last Modified: 26 Apr 2022 09:17

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