Saber-Samandari, Samaneh and Saber-Samandari, Saeed and Gazi, Mustafa and Cebeci, Fevzi Çakmak and Talasaz, Emad (2013) Synthesis, characterization and application of cellulose based nano-biocomposite hydrogels. Journal of Macromolecular Science Part A Pure and Applied Chemistry, 50 (11). pp. 1133-1141. ISSN 1060-1325 (Print) 1520-5738 (Online)
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Official URL: http://dx.doi.org/10.1080/10601325.2013.829362
Abstract
Nano-hydroxyapatite/cellulose-graft-polyacrylamide biocomposite hydrogels of different molar ratios were prepared to examine their potential application as a carrier for colon targeted drug delivery in vitro. The particle size of the synthesized nano-hydroxyapatite was found to be 122nm. The swelling behavior of the composite hydrogels was observed in acidic and basic aqueous solution that simulated lower small intestine, colon and stomach fluids. The hydrogel could be applied in drug-delivery systems and acetylsalicylic acid was used as a model compound to test such a possibility. Finally, the synthesized biocomposite hydrogels with the 96.97% maximum encapsulation and 85.67% release efficiency in the basic medium were found to be a suitable candidate to carry and release of colon-targeted drugs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | acrylamide; cellulose; composite; hydrogel; nano-hydroxyapatite |
| Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology > TP1080 Polymers and polymer manufacture |
| Divisions: | Faculty of Engineering and Natural Sciences > Academic programs > Materials Science & Eng. Faculty of Engineering and Natural Sciences |
| Depositing User: | Fevzi Çakmak Cebeci |
| Date Deposited: | 21 Jan 2014 14:24 |
| Last Modified: | 01 Aug 2019 14:51 |
| URI: | https://research.sabanciuniv.edu/id/eprint/22949 |
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