Alteration in autophagic-lysosomal potential during ageing and neurological diseases: the microRNA perspective

Tekirdağ, Kumsal Ayşe and Deniz Gülfem, Öztürk and Gözüaçık, Devrim (2013) Alteration in autophagic-lysosomal potential during ageing and neurological diseases: the microRNA perspective. (Accepted/In Press)

There is a more recent version of this item available.
Full text not available from this repository. (Request a copy)


Macroautophagy (shortly autophagy) is an evolutionary conserved degradation pathway that targets cytoplasmic substrates including long-lived proteins, protein aggregates and damaged organelles, and leads to their degradation in lysosomes. Beyond its role in adaptation to cellular stresses such as nutrient deprivation, hypoxia and toxins; recent studies attributed a central role to autophagy in aging and lifespan determination. Moreover, alterations and abnormalities of autophagy may contribute to a number of important health problems, including cancer, myopathies, metabolic disorders, and the focus of this review, ageing-related neurodegenerative diseases. Some disease-related, mutant and aggregation-prone proteins may be cleared by autophagy, on the other hand, disregulation of the autophagy pathways may also contribute to neurotoxicity observed in degenerative pathologies. microRNAs (miRNAs) are endogenous regulators of gene expression, and their deregulation was reported in several ageing-related conditions. Studies in the last few years introduced miRNAs as novel and potent regulators of autophagy. In this review article, we will summarize the connection between autophagy, ageing and Alzheimer’s, Parkinson’s and Huntington’s diseases, and discuss the role of autophagy-related miRNAs in this context.
Item Type: Article
Additional Information: New journal to be indexed in SCI DG is the corresponding author
Uncontrolled Keywords: Autophagy, mitophagy, microRNA, neurodegenerative diseases, aging, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RB Pathology
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Devrim Gözüaçık
Date Deposited: 28 Sep 2013 23:00
Last Modified: 01 Aug 2019 10:56

Available Versions of this Item

Actions (login required)

View Item
View Item