Antibody array-based immunosensor for detecting cardiovascular disease risk markers

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Timuçin, Can and Gül, Özgür and Kütük, Özgür and Başağa, Hüveyda (2012) Antibody array-based immunosensor for detecting cardiovascular disease risk markers. Journal of Immunoassay and Immunochemistry, 33 (3). pp. 275-290. ISSN 1532-1819

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Quantitative detection of proteins in multiplexed platforms presents technical advantages at clinical and laboratory settings compared to the monoplex ELISA method. With this purpose, we implemented a pilot study using in-house-designed sandwich-type antibody array for multiplexed detection of seven cardiovascular disease (CVD) risk markers and compared the performance of our immunosensor to conventional ELISA kits. Results indicated that our immunosensor can determine serum amyloid A (SAA), vascular cell adhesion molecule (VCAM), and myoglobin (MYO) concentrations accurately, precisely, and above all very much similar to ELISA. Hence, multiplexed detection and quantification of SAA, VCAM, and MYO with our immunosensor can be considered as a potential multiplexed alternative to the ELISA method.
Item Type: Article
Uncontrolled Keywords: ELISA; method comparison; multiplexed immunosensor; myoglobin; serum amyloid a; vascular cell adhesion molecule
Subjects: T Technology > T Technology (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Hüveyda Başağa
Date Deposited: 27 Oct 2012 22:22
Last Modified: 31 Jul 2019 12:41

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