Registration of brain tumor images using hyper-elastic regularization

In this paper, we present a method to estimate a deformation field between two instances of a brain volume having tumor. The novelties include the assessment of the disease progress by observing the healthy tissue deformation and usage of the Neo-Hookean strain energy density model as a regularizer in deformable registration framework. Implementations on synthetic and patient data provide promising results, which might have relevant use in clinical problems.