A New 3-D automated computational method to evaluate in-stent neointimal hyperplasia in in-vivo intravascular optical coherence tomography pullbacks

Unal, Gozde and Gurmeric, Serhan and Isguder, Gozde Gul and Carlier, Stephane (2009) A New 3-D automated computational method to evaluate in-stent neointimal hyperplasia in in-vivo intravascular optical coherence tomography pullbacks. In: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2009 - 12th International Conference, London, UK

[thumbnail of This is a RoMEO green publisher - Author can archive pre-print (ie pre-refereeing) / author can archive post-print (ie final draft post-refereeing)] PDF (This is a RoMEO green publisher - Author can archive pre-print (ie pre-refereeing) / author can archive post-print (ie final draft post-refereeing))
Unal-miccai2009.pdf

Download (1MB)
[thumbnail of Unal-miccai2009.pdf] PDF
Unal-miccai2009.pdf

Download (1MB)
[thumbnail of 57620776Miccai09Published.pdf] PDF
57620776Miccai09Published.pdf

Download (1MB)
[thumbnail of 57620776Miccai09Published.pdf] PDF
57620776Miccai09Published.pdf

Download (1MB)

Abstract

Abstract. Detection of stent struts imaged in vivo by optical coherence tomography (OCT) after percutaneous coronary interventions (PCI) and quantification of in-stent neointimal hyperplasia (NIH) are important. In this paper, we present a new computational method to facilitate the physician in this endeavor to assess and compare new (drug-eluting) stents. We developed a new algorithm for stent strut detection and utilized splines to reconstruct the lumen and stent boundaries which provide automatic measurements of NIH thickness, lumen and stent area. Our original approach is based on the detection of stent struts unique characteristics: bright reflection and shadow behind. Furthermore, we present for the first time to our knowledge a rotation correction method applied across OCT cross-section images for 3D reconstruction and visualization of reconstructed lumen and stent boundaries for further analysis in the longitudinal dimension of the coronary artery. Our experiments over OCT cross-sections taken from 7 patients presenting varying degrees of NIH after PCI illustrate a good agreement between the computer method and expert evaluations: Bland-Altmann analysis revealed a mean difference for lumen cross-section area of 0.11 ± 0.70mm2 and for the stent cross-section area of 0.10 ± 1.28mm2.
Item Type: Papers in Conference Proceedings
Subjects: Q Science > QA Mathematics > QA075 Electronic computers. Computer science
Divisions: Faculty of Engineering and Natural Sciences
Depositing User: Gözde Ünal
Date Deposited: 02 Dec 2009 13:22
Last Modified: 26 Apr 2022 08:53
URI: https://research.sabanciuniv.edu/id/eprint/12999

Actions (login required)

View Item
View Item