Bcl-2 protein family: Implications in vascular apoptosis and atherosclerosis

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Kütük , Özgür and Başağa, Hüveyda (2006) Bcl-2 protein family: Implications in vascular apoptosis and atherosclerosis. Apoptosis, 11 (10). pp. 1661-1675. ISSN 1360-8185 (Print) 1573-675X (Online)

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Official URL: http://dx.doi.org/10.1007/s10495-006-9402-7


Apoptosis has been recognized as a central component in the pathogenesis of atherosclerosis, in addition to the other human pathologies such as cancer and diabetes. The pathophysiology of atherosclerosis is complex, involving both apoptosis and proliferation at different phases of its progression. Oxidative modification of lipids and inflammation differentially regulate the apoptotic and proliferative responses of vascular cells during progression of the atherosclerotic lesion. Bcl-2 proteins act as the major regulators of extrinsic and intrinsic apoptosis signalling pathways and more recently it has become evident that they mediate the apoptotic response of vascular cells in response to oxidation and inflammation either in a provocative or an inhibitory mode of action. Here we address Bcl-2 proteins as major therapeutic targets for the treatment of atherosclerosis and underscore the need for the novel preventive and therapeutic interventions against atherosclerosis, which should be designed in the light of molecular mechanisms regulating apoptosis of vascular cells in atherosclerotic lesions.

Item Type:Article
Uncontrolled Keywords:apoptosis; atherosclerosis; Bcl-2; oxidation; inflammation
Subjects:Q Science > QH Natural history
ID Code:595
Deposited By:Hüveyda Başağa
Deposited On:14 Feb 2007 02:00
Last Modified:25 May 2011 14:03

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