Biomimicry in bio-manufacturing: developments in melt electrospinning writing technology towards hybrid biomanufacturing

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Afghah, Seyedeh Ferdows and Dikyol, Caner and Altunbek, Mine and Koç, Bahattin (2019) Biomimicry in bio-manufacturing: developments in melt electrospinning writing technology towards hybrid biomanufacturing. Applied Sciences . ISSN 2076-3417 Published Online First http://dx.doi.org/10.3390/app9173540

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Official URL: http://dx.doi.org/10.3390/app9173540


Melt electrospinning writing has been emerged as a promising technique in the field of tissue engineering, with the capability of fabricating controllable and highly ordered complex three-dimensional geometries from a wide range of polymers. This three-dimensional (3D) printing method can be used to fabricate scaffolds biomimicking extracellular matrix of replaced tissue with the required mechanical properties. However, controlled and homogeneous cell attachment on melt electrospun fibers is a challenge. The combination of melt electrospinning writing with other tissue engineering approaches, called hybrid biomanufacturing, has introduced new perspectives and increased its potential applications in tissue engineering. In this review, principles and key parameters, challenges, and opportunities of melt electrospinning writing, and particularly, recent approaches and materials in this field are introduced. Subsequently, hybrid biomanufacturing strategies are presented for improved biological and mechanical properties of the manufactured porous structures. An overview of the possible hybrid setups and applications, future perspective of hybrid processes, guidelines, and opportunities in different areas of tissue/organ engineering are also highlighted.

Item Type:Article
Uncontrolled Keywords:melt electrospinning writing; hybrid biomanufacturing; three-dimensional scaffold; tissue engineering
ID Code:39139
Deposited By:Bahattin Koç
Deposited On:29 Aug 2019 12:42
Last Modified:29 Aug 2019 12:42

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