3D bioprinting of cell-laden molecularly engineered PEG-based hydrogels
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Akdeniz Skvortsov, Gözde and Piluso, Susanna and Altunbek, Mine and Khani, Navid and Oosterwyck, Hans Van and Ferraris , Eleonora and Patterson, Jennifer and Koç, Bahattin (2018) 3D bioprinting of cell-laden molecularly engineered PEG-based hydrogels. In: Biofabrication Conference 2018, Wurzberg, Germany
A major limitation in tissue engineering is the ability to prepare constructs that can mimic the complex structure of natural tissues. A solution to address this challenge is provided by 3D printing that allows the preparation of cell-laden constructs with a highly organized structure. Specifically, here we present a biofabrication strategy where a molecularly engineered polyethylene glycol (PEG)-based hydrogel formulation was developed and used in a 3D bioprinting process without the use of any cytotoxic photoinitiators and photocrosslinking. The viability and proliferation of cell-laden bioprinted constructs were also evaluated.
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