Biomanufacturing of customized modular scaffolds for critical bone defects
Koç, Bahattin and Acar, Anıl Ahmet and Weightman, Andrew and Cooper, Glen and Blunn, Gordon and Bartolo, Paulo (2019) Biomanufacturing of customized modular scaffolds for critical bone defects. CIRP Annals - Manufacturing Technology, 68 (1). pp. 209-212. ISSN 0007-8506 (Print) 1726-0604 (Online)
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Official URL: http://dx.doi.org/10.1016/j.cirp.2019.04.106
There is a significant unmet clinical need for modular and customized porous biodegradable constructs (scaffolds) for non-union large bone loss injuries. This paper proposes modelling and biomanufacturing of modular and customizable porous constructs for patient-specific critical bone defects. A computational geometry-based algorithm was developed to model modular porous constructs using a parametric femur model based on the frequency of common injuries. The generated modular constructs are used to generate biomimetic path planning for three-dimensional (3D) printing of modular scaffold pieces. The developed method can be used for regenerating bone tissue for treating non-union large bone defects.
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