Biomanufacturing of customized modular scaffolds for critical bone defects

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Koç, Bahattin and Acar, Anıl Ahmet and Weightman, Andrew and Cooper, Glen and Blunn, Gordon and Bartolo, Paulo (2019) Biomanufacturing of customized modular scaffolds for critical bone defects. CIRP Annals - Manufacturing Technology, 68 (1). pp. 209-212. ISSN 0007-8506 (Print) 1726-0604 (Online)

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Official URL: http://dx.doi.org/10.1016/j.cirp.2019.04.106


There is a significant unmet clinical need for modular and customized porous biodegradable constructs (scaffolds) for non-union large bone loss injuries. This paper proposes modelling and biomanufacturing of modular and customizable porous constructs for patient-specific critical bone defects. A computational geometry-based algorithm was developed to model modular porous constructs using a parametric femur model based on the frequency of common injuries. The generated modular constructs are used to generate biomimetic path planning for three-dimensional (3D) printing of modular scaffold pieces. The developed method can be used for regenerating bone tissue for treating non-union large bone defects.

Item Type:Article
Uncontrolled Keywords:Additive manufacturing; Biologically inspired design; Biomanufacturing
Subjects:T Technology > TP Chemical technology > TP0248.13 Biotechnology
T Technology > TP Chemical technology > TP1080 Polymers and polymer manufacture
ID Code:38612
Deposited By:Bahattin Koç
Deposited On:27 Aug 2019 14:59
Last Modified:27 Aug 2019 14:59

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