Bakan, Feray (2018) Gene delivery by hydroxyapatite and calcium phosphate nanoparticles: a review of novel and recent applications. In: Thirumalai, Jagannathan, (ed.) Hydroxyapatite: Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets. IntechOpen, London, UK, pp. 157-176. ISBN 978-953-51-3804-4 (Print) 978-953-51-3805-1 (Online)
![[thumbnail of book chapter]](https://research.sabanciuniv.edu/style/images/fileicons/application_pdf.png)
PDF (book chapter)
bookchapter_FB.pdf
Download (4MB)
Official URL: http://dx.doi.org/10.5772/intechopen.71062
Abstract
Gene therapy is a targeted therapy which can be used in the treatment of various acquired
and inherited diseases. Inhabitation of a gene function, restoring or improving a gene, or
gaining a new function can be achieved by gene therapy strategies. The most crucial step
in this therapy is delivering the therapeutic material to the target. Nanosized calcium
phosphates (CaPs) have been considered as promising carriers due to their excellent biocompatibility.
In this chapter, the delivery of DNA, siRNA, and miRNA by using CaP
nanocarriers were compiled in detail and the main parameters which can affect the carrier
properties and thus the gene transfer efficiency were also discussed.
| Item Type: | Book Section / Chapter |
|---|---|
| Subjects: | Q Science > Q Science (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Sabancı University Nanotechnology Research and Application Center Faculty of Engineering and Natural Sciences |
| Depositing User: | Feray Bakan |
| Date Deposited: | 12 Aug 2018 20:47 |
| Last Modified: | 22 May 2019 14:08 |
| URI: | https://research.sabanciuniv.edu/id/eprint/35722 |
Actions (login required)
- View Item