The crosstalk between miRNAs and autophagy in cancer progression

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Bayraktar, Öznur and Gözüaçık, Devrim (2018) The crosstalk between miRNAs and autophagy in cancer progression. In: Fayyaz, Sundas and Farooqi, Ammad Ahmad, (eds.) Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs. Springer International Publishing, USA, pp. 279-291. ISBN 978-3-319-71552-0 (Print) 978-3-319-71553-7 (Online)

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Official URL: http://dx.doi.org/10.1007/978-3-319-71553-7_15


MicroRNAs (miRNAs) are small (17-25 nucleotide-long), non-coding RNAs that modulate and repress the expression of their target mRNAs. Aberrant expression of miRNAs is linked to many human diseases including cancer. The change in expression levels of miRNAs may also result in impaired autophagy. Autophagy is a double-edged sword during cancer initiation and progression. At the beginning of tumorigenesis, autophagy suppresses tumor formation by the removal of defective organelles such as mitochondria; restricting oxidative stress and protecting genome stability. However, in the later stages of tumor formation, autophagy is a survival pathway for tumor cells under the low levels of oxygen (hypoxia), deprivation of growth factors and glucose. The main focus of this chapter is the interplay between miRNAs and autophagy during initiation and progression of cancer.

Item Type:Book Section / Chapter
Subjects:Q Science > Q Science (General)
R Medicine > R Medicine (General)
ID Code:35349
Deposited By:Devrim Gözüaçık
Deposited On:08 Aug 2018 10:46
Last Modified:22 May 2019 14:05

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