3D Bioprinting of aortic structures with HDF cells
Koç, Bahattin and Özler, Saime Burçe and Küçükgül, Can and Altunbek, Mine and Sen, O. and Çulha, M. (2014) 3D Bioprinting of aortic structures with HDF cells. In: Termis EU 2014 Congress, Genova, Italy
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Traditionally, tissue engineering strategies for damaged or diseased large blood vessels are based on scaffolds. Following the cell-seeding and surgical implantation of scaffold, there could be immunogenic reactions and complications due to the limitations of scaffold biomaterials. Therefore, recent vascular tissue engineering studies tends to scaffold-free techniques [1, 2]. In this research, a novel biomimetic computer-aided design and three-dimensional (3D) bioprinting techniques are developed to optimize bioprinting of scaffold-free macrovascular structures biomimicking a real human aorta. Live human dermal fibroblast cells (HDF) aggregates and support structures (hydrogels) are 3D bioprinted layer-by-layer according to the developed self-supporting computer model to form biomimetic aortic vessel structures.
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