3D hybrid wound devices for spatiotemporally controlled release kinetics

Özbolat, İbrahim T. and Koç, Bahattin (2012) 3D hybrid wound devices for spatiotemporally controlled release kinetics. Computer Methods and Programs in Biomedicine, 108 (3). pp. 922-931. ISSN 0169-2607 (Print) 1872-7565 (Online)

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Official URL: http://dx.doi.org/10.1016/j.cmpb.2012.05.004


This paper presents localized and temporal control of releasekinetics over 3-dimensional (3D) hybridwounddevices to improve wound-healing process. Imaging study is performed to extract wound bed geometry in 3D. Non-Uniform Rational B-Splines (NURBS) based surface lofting is applied to generate functionally graded regions. Diffusion-based releasekinetics model is developed to predict time-based release of loaded modifiers for functionally graded regions. Multi-chamber single nozzle solid freeform dispensing system is used to fabricate wounddevices with controlled dispensing concentration. Spatiotemporal control of biological modifiers thus enables a way to achieve target delivery to improve wound healing.

Item Type:Article
Uncontrolled Keywords:Wound healing, Release kinetics, Hybrid wound devices
Subjects:T Technology > TP Chemical technology > TP0248.13 Biotechnology
R Medicine > R Medicine (General) > R856-857 Biomedical engineering. Electronics. Instrumentation
R Medicine > R Medicine (General) > R858-859.7 Computer applications to medicine. Medical informatics
T Technology > TP Chemical technology > TP1080 Polymers and polymer manufacture
ID Code:20926
Deposited By:Bahattin Koç
Deposited On:02 Dec 2012 14:34
Last Modified:31 Jul 2019 15:14

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