A numerical approach for dielectrophoretic characterization and separation of human hematopoietic cells

Abstract

Rapid and reliable characterization of hematopoietic cells still remain the first step for precise medicine. Diagnosis of various diseases, ranging from infectious to cancer, relies on quantification of hematopoietic cells from blood. Therefore, there is an emerging need for label-free, lowcost, time-efficient, reproducible and quantitative characterization tools for the blood cells. Addressed herein is a numerical analysis for dielectrophoretic characterization of red blood cells, T-lymphocytes, B-lymphocytes and monocytes, which quantitatively incorporate with the membrane features of these cells to provide more insight into their dielectrophoretic responses.