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In vitro/in vivo evaluation of gamma-aminobutyric acid-loadedN,N-dimethylacrylamide-based pegylated polymeric nanoparticles for brain delivery to treat epilepsy

Yurtdaş Kırımlıoğlu, Gülsel and Menceloğlu, Yusuf Z. and Erol, Kevser and Yazan, Yasemin (2016) In vitro/in vivo evaluation of gamma-aminobutyric acid-loadedN,N-dimethylacrylamide-based pegylated polymeric nanoparticles for brain delivery to treat epilepsy. Journal of Microencapsulation . ISSN 0265-2048 (Print) 1464-5246 (Online) Published Online First http://dx.doi.org/10.1080/02652048.2016.1234515

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Official URL: http://dx.doi.org/10.1080/02652048.2016.1234515

Abstract

Objectives of this study were the delivery of gamma aminobutyric acid (GABA) into the brain by means of developing brain targeted, nanosized, non-toxic and biocompatible polymeric nanoparticles, and investi- gating their effectiveness in epilepsy. For this purpose, GABA conjugated N,N-dimethylacrylamide-based pegylated nanoparticles were designed and characterised for particle size, zeta potential, pH, morphology, DSC, XRD, FTIR, GABA quantification and in vitro release. Formulations showed smaller particle size, cationic zeta potential characteristic, possible GABA polymeric matrix interaction and prolonged release pattern. Brain responses were examined using epileptic rats. Both formulations prepared were found to increase latency of seizure, decrease ending time of convulsion, duration of severe convulsion and mortal- ity rate significantly compared with GABA solution. When GABA concentration was measured in Stratum corsatum, there was no statistical difference between GABA solution and formulations. All findings sug- gested enhancement in all phases of seizures indicating efficient delivery of GABA into the brain via formulations.

Item Type:Article
Uncontrolled Keywords:Gamma-aminobutyric acid, pegylated polymeric nanoparticles, stability, epilepsy, pharmacodynamics
Subjects:Q Science > QD Chemistry > QD241-441 Organic chemistry
T Technology > TP Chemical technology > TP1080 Polymers and polymer manufacture
ID Code:29950
Deposited By:Yusuf Z. Menceloğlu
Deposited On:10 Nov 2016 10:42
Last Modified:10 Nov 2016 10:42

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