Survival signals induced by low concentrations of 27-hydroxycholesterol in human monocytic cells via ERK activation
Vuruşaner Aktaş, Beyza and Poli, Giuseppe and Başağa, Hüveyda (2012) Survival signals induced by low concentrations of 27-hydroxycholesterol in human monocytic cells via ERK activation. In: Society for Free Radical Research International 16th Biennial Meeting, Imperial College London, UK
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Official URL: http://dx.doi.org/10.1016/j.freeradbiomed.2012.08.489
Oxysterols are oxidized derivatives of cholesterol, most likely contributing to the development of atherosclerosis. On the basis of the clear findings by previous workers about oxysterol-mediated induction of survival pathways aside that of death pathways, we aimed to identify the main genes and related products involved in the transduction of survival signals and elucidate the relevant molecular mechanisms in human macrophagic cells challenged with 27-hydroxycholesterol in the low micromolar range.
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