Computer-aided 4D modeling of hydrolytic degradation in micropatterned bioresorbable membranes
Özbolat, İbrahim T. and Marchany, Michelle and Joseph, A. Gardella, Jr., and Koç, Bahattin (2013) Computer-aided 4D modeling of hydrolytic degradation in micropatterned bioresorbable membranes. Journal of Medical Devices, 7 (2). ISSN 1932-6181 (Print) 1932-619X (Online)
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Official URL: http://dx.doi.org/10.1115/1.4024158
Real-time degradation studies of bioresorbable polymers can take weeks, months, and even years to conduct. For this reason, developing and validating mathematical models that describe and predict degradation can provide a means to accelerate the development of materials and devices for controlled drug release. This study aims to develop and experimentally validate a computer-aided model that simulates the hydrolytic degradation kinetics of bioresorbable polymeric micropatterned membranes for tissue engineering applications. Specifically, the model applies to circumstances that are conducive for the polymer to undergo surface erosion. The developed model provides a simulation tool enabling the prediction and visualization of the dynamic geometry of the degrading membrane. In order to validate the model, micropatterned polymeric membranes were hydrolytically degraded in vitro and the morphological changes were analyzed using optical microscopy. The model is then extended to predict spatiotemporal degradation kinetics of variational micropatterned architectures.
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