Cancer resistance and metastasis are maintained through oxidative phosphorylation

Uslu, Cemile and Kapan, Eda and Lyakhovich, Alex (2024) Cancer resistance and metastasis are maintained through oxidative phosphorylation. Cancer Letters, 587 . ISSN 0304-3835 (Print) 1872-7980 (Online)

Full text not available from this repository. (Request a copy)


Malignant tumors have increased energy requirements due to growth, differentiation or response to stress. A significant number of studies in recent years have described upregulation of mitochondrial genes responsible for oxidative phosphorylation (OXPHOS) in some tumors. Although OXPHOS is replaced by glycolysis in some tumors (Warburg effect), both processes can occur simultaneously during the evolution of the same malignancies. In particular, chemoresistant and/or cancer stem cells appear to find a way to activate OXPHOS and metastasize. In this paper, we discuss recent work showing upregulation of OXPHOS in chemoresistant tumors and cell models. In addition, we show an inverse correlation of OXPHOS gene expression with the survival time of cancer patients after chemotherapy and discuss combination therapies for resistant tumors.
Item Type: Article
Uncontrolled Keywords: Cancer chemoprevention; Cancer chemoresistance; Cancer stem cells; Drug repurposing; Mitochondrial respiration; Oxidative phosphorylation; Personalized medicine; Targeted therapy
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Alex Lyakhovich
Date Deposited: 09 Jun 2024 16:32
Last Modified: 09 Jun 2024 16:32

Actions (login required)

View Item
View Item