Downregulated NPAS4 in multiple brain regions is associated with major depressive disorder

Selçuk, Berkay and Aksu, Tuana and Dereli, Onur and Adebali, Ogün (2023) Downregulated NPAS4 in multiple brain regions is associated with major depressive disorder. Scientific Reports, 13 (1). ISSN 2045-2322

Full text not available from this repository. (Request a copy)


Major Depressive Disorder (MDD) is a commonly observed psychiatric disorder that affects more than 2% of the world population with a rising trend. However, disease-associated pathways and biomarkers are yet to be fully comprehended. In this study, we analyzed previously generated RNA-seq data across seven different brain regions from three distinct studies to identify differentially and co-expressed genes for patients with MDD. Differential gene expression (DGE) analysis revealed that NPAS4 is the only gene downregulated in three different brain regions. Furthermore, co-expressing gene modules responsible for glutamatergic signaling are negatively enriched in these regions. We used the results of both DGE and co-expression analyses to construct a novel MDD-associated pathway. In our model, we propose that disruption in glutamatergic signaling-related pathways might be associated with the downregulation of NPAS4 and many other immediate-early genes (IEGs) that control synaptic plasticity. In addition to DGE analysis, we identified the relative importance of KEGG pathways in discriminating MDD phenotype using a machine learning-based approach. We anticipate that our study will open doors to developing better therapeutic approaches targeting glutamatergic receptors in the treatment of MDD.
Item Type: Article
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Onur Dereli
Date Deposited: 08 Feb 2024 15:50
Last Modified: 08 Feb 2024 15:50

Actions (login required)

View Item
View Item