Update on mesenchymal stem cells: a crucial player in cancer immunotherapy

Taeb, Shahram and Rostamzadeh, Davoud and Mafi, Sahar and Mofatteh, Mohammad and Zarrabi, Ali and Hushmandi, Kiavash and Safari, Arash and Khodamoradi, Ehsan and Najafi, Masoud (2024) Update on mesenchymal stem cells: a crucial player in cancer immunotherapy. Current Molecular Medicine, 24 (1). pp. 98-113. ISSN 1566-5240 (Print) 1875-5666 (Online)

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The idea of cancer immunotherapy has spread, and it has made tremendous progress with the advancement of new technology. Immunotherapy, which serves to assist the natural defenses of the body in eradicating cancerous cells, is a remarkable achievement that has revolutionized both cancer research and cancer treatments. Currently, the use of stem cells in immunotherapy is widespread and shares a special characteristic, including cancer cell migration, bioactive component release, and immunosuppressive activity. In the context of cancer, mesenchymal stem cells (MSCs) are rapidly being identified as vital stromal regulators of tumor progression. MSCs therapy has been implicated in treating a wide range of diseases, including bone damage, autoimmune diseases, and particularly hematopoietic abnormalities, providing stem cell-based therapy with an extra dimension. Moreover, the implication of MSCs does not have ethical concerns, and the complications known in pluripotent and totipotent stem cells are less common in MSCs. MSCs have a lot of distinctive characteristics that, when coupled, make them excellent for cellular-based immunotherapy and as vehicles for gene and drug delivery in a variety of inflammations and malignancies. MSCs can migrate to the inflammatory site and exert immunomodulatory responses via cell-to-cell contacts with lymphocytes by generating soluble substances. In the current review, we discuss the most recent research on the immunological characteristics of MSCs, their use as immunomodulatory carriers, techniques for approving MSCs to adjust their immunological contour, and their usages as vehicles for delivering therapeutic as well as drugs and genes engineered to destroy tumor cells.
Item Type: Article
Uncontrolled Keywords: cancer treatment; engineered mesenchymal; immunomodulatory responses; immunotherapy; Mesenchymal stem cells; stem cells
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 06 Feb 2024 21:30
Last Modified: 06 Feb 2024 21:30
URI: https://research.sabanciuniv.edu/id/eprint/48803

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