Rhabdomyosarcoma: current therapy, challenges, and future approaches to treatment strategies

Zarrabi, Ali and Perrin, David and Kavoosi, Mahboubeh and Sommer, Micah and Sezen, Serap and Mehrbod, Parvaneh and Bhushan, Bhavya and Machaj, Filip and Rosik, Jakub and Kawalec, Philip and Afifi, Saba and Bolandi, Seyed Mohammadreza and Koleini, Peiman and Taheri, Mohsen and Madrakian, Tayyebeh and Łos, Marek J. and Lindsey, Benjamin and Çakır, Nilüfer and Zarepour, Atefeh and Hushmandi, Kiavash and Fallah, Ali and Koç, Bahattin and Khosravi, Arezoo and Ahmadi, Mazaher and Logue, Susan and Orive, Gorka and Pecic, Stevan and Gordon, Joseph W. and Ghavami, Saeid (2023) Rhabdomyosarcoma: current therapy, challenges, and future approaches to treatment strategies. Cancers, 15 (21). ISSN 2072-6694

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Rhabdomyosarcoma is a rare cancer arising in skeletal muscle that typically impacts children and young adults. It is a worldwide challenge in child health as treatment outcomes for metastatic and recurrent disease still pose a major concern for both basic and clinical scientists. The treatment strategies for rhabdomyosarcoma include multi-agent chemotherapies after surgical resection with or without ionization radiotherapy. In this comprehensive review, we first provide a detailed clinical understanding of rhabdomyosarcoma including its classification and subtypes, diagnosis, and treatment strategies. Later, we focus on chemotherapy strategies for this childhood sarcoma and discuss the impact of three mechanisms that are involved in the chemotherapy response including apoptosis, macro-autophagy, and the unfolded protein response. Finally, we discuss in vivo mouse and zebrafish models and in vitro three-dimensional bioengineering models of rhabdomyosarcoma to screen future therapeutic approaches and promote muscle regeneration.
Item Type: Article
Uncontrolled Keywords: alveolar rhabdomyosarcoma; apoptosis; autophagy; autophagy; bioengineering; tumor stiffness; unfolded protein response
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Integrated Manufacturing Technologies Research and Application Center
Depositing User: Ali Fallah
Date Deposited: 06 Feb 2024 15:34
Last Modified: 06 Feb 2024 15:34
URI: https://research.sabanciuniv.edu/id/eprint/48709

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