(Nano)platforms in bladder cancer therapy: challenges and opportunities

Ashrafizadeh, Milad and Zarrabi, Ali and Karimi-Maleh, Hassan and Taheriazam, Afshin and Mirzaei, Sepideh and Hashemi, Mehrdad and Hushmandi, Kiavash and Makvandi, Pooyan and Nazarzadeh Zare, Ehsan and Sharifi, Esmaeel and Goel, Arul and Wang, Lingzhi and Ren, Jun and Nuri Ertas, Yavuz and Kumar, Alan Prem and Wang, Yuzhuo and Rabiee, Navid and Sethi, Gautam and Ma, Zhaowu (2023) (Nano)platforms in bladder cancer therapy: challenges and opportunities. Bioengineering and Translational Medicine, 8 (1). ISSN 2380-6761

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Urological cancers are among the most common malignancies around the world. In particular, bladder cancer severely threatens human health due to its aggressive and heterogeneous nature. Various therapeutic modalities have been considered for the treatment of bladder cancer although its prognosis remains unfavorable. It is perceived that treatment of bladder cancer depends on an interdisciplinary approach combining biology and engineering. The nanotechnological approaches have been introduced in the treatment of various cancers, especially bladder cancer. The current review aims to emphasize and highlight possible applications of nanomedicine in eradication of bladder tumor. Nanoparticles can improve efficacy of drugs in bladder cancer therapy through elevating their bioavailability. The potential of genetic tools such as siRNA and miRNA in gene expression regulation can be boosted using nanostructures by facilitating their internalization and accumulation at tumor sites and cells. Nanoparticles can provide photodynamic and photothermal therapy for ROS overgeneration and hyperthermia, respectively, in the suppression of bladder cancer. Furthermore, remodeling of tumor microenvironment and infiltration of immune cells for the purpose of immunotherapy are achieved through cargo-loaded nanocarriers. Nanocarriers are mainly internalized in bladder tumor cells by endocytosis, and proper design of smart nanoparticles such as pH-, redox-, and light-responsive nanocarriers is of importance for targeted tumor therapy. Bladder cancer biomarkers can be detected using nanoparticles for timely diagnosis of patients. Based on their accumulation at the tumor site, they can be employed for tumor imaging. The clinical translation and challenges are also covered in current review.
Item Type: Article
Uncontrolled Keywords: bladder cancer; clinical application; drug delivery; phototherapy; smart nanocarriers
Divisions: Faculty of Engineering and Natural Sciences
Depositing User: Milad Ashrafizadeh
Date Deposited: 06 Sep 2023 16:06
Last Modified: 06 Sep 2023 16:06
URI: https://research.sabanciuniv.edu/id/eprint/47790

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