Biomedical applications of engineered heparin-based materials

Nazarzadeh Zare, Ehsan and Khorsandi, Danial and Zarepour, Atefeh and Yılmaz, Hülya and Agarwal, Tarun and Houshmand Rezaghol, Sara and Mohammadinejad, Reza and Özdemir, Fatma and Sahin, Onur and Adıgüzel, Sevin and Khan, Haroon and Zarrabi, Ali and Sharifi, Esmaeel and Kumar, Arun and Mostafavi, Ebrahim and Kouchehbaghi, Negar Hosseinzadeh and Mattoli, Virgilio and Zhang, Feng and Jucaud, Vadim and Najafabadi, Alireza Hassani and Khademhosseini, Ali (2024) Biomedical applications of engineered heparin-based materials. Bioactive Materials, 31 . pp. 87-118. ISSN 2452-199X

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Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic backbone. Due to its fascinating chemical and physical properties, nontoxicity, biocompatibility, and biodegradability, heparin has been extensively used in different fields of medicine, such as cardiovascular and hematology. This review highlights recent and future advancements in designing materials based on heparin for various biomedical applications. The physicochemical and mechanical properties, biocompatibility, toxicity, and biodegradability of heparin are discussed. In addition, the applications of heparin-based materials in various biomedical fields, such as drug/gene delivery, tissue engineering, cancer therapy, and biosensors, are reviewed. Finally, challenges, opportunities, and future perspectives in preparing heparin-based materials are summarized.
Item Type: Article
Uncontrolled Keywords: Biological; Biomedical applications; Heparin; Nanomaterials; Physicochemical; Preparation
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: Hülya Yılmaz
Date Deposited: 02 Sep 2023 16:10
Last Modified: 02 Sep 2023 16:10

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