Axonal transport defects in retinal Ganglion cell diseases

Okan, İskalen Cansu and Özdemir, Fatma and Ağca, Cavit (2023) Axonal transport defects in retinal Ganglion cell diseases. In: Ash, John D. and Pierce, Eric and Anderson, Robert E. and Rickman, Catherine Bowes and Hollyfield, Joe G. and Grimm, Christian, (eds.) Retinal Degenerative Diseases XIX: Mechanisms and Experimental Therapy. Advances in Experimental Medicine and Biology, 1415. Springer Cham, Switzerland, pp. 223-227. ISBN 978-3-031-27680-4 (Print) 978-3-031-27681-1 (Online)

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For the survival and maintenance of retinal ganglion cells (RGCs), axonal transportation is fundamental. Axonal transportation defects can cause severe neuropathies leading to neuronal loss. Axonal transport defects usually precede axonal degeneration and RGC loss in disease models. To date, the main causes of axonal transport defects have not been fully understood. Therefore, elucidation of the mechanisms that lead to transport defects will help us to develop novel therapeutic targets and early diagnostic tools. In this review, we provide an overview of optic neuropathies and axonal degeneration with a focus on axonal transport.
Item Type: Book Section / Chapter
Uncontrolled Keywords: Axonal degeneration; Axonal transport; Glaucoma; Mitochondria; OPA1
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Cavit Ağca
Date Deposited: 07 Aug 2023 20:37
Last Modified: 07 Aug 2023 20:45

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