An overview of the role of adipokines in cardiometabolic diseases

Farkhondeh, Tahereh and Llorens, Silvia and Pourbagher-Shahri, Ali Mohammad and Ashrafizadeh, Milad and Talebi, Marjan and Shakibaei, Mehdi and Samarghandian, Saeed (2020) An overview of the role of adipokines in cardiometabolic diseases. Molecules, 25 (21). ISSN 1420-3049

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Obesity as an independent risk factor for cardiovascular diseases (CVDs) leads to an increase in morbidity, mortality, and a shortening of life span. The changes in heart structure and function as well as metabolic profile are caused by obese people, including those free of metabolic disorders. Obesity alters heart function structure and affects lipid and glucose metabolism, blood pressure, and increase inflammatory cytokines. Adipokines, specific cytokines of adipocytes, are involved in the progression of obesity and the associated co-morbidities. In the current study, we review the scientific evidence on the effects of obesity on CVDs, focusing on the changes in adipokines. Several adipokines have anti-inflammatory and cardioprotective effects comprising omentin, apelin, adiponectin, and secreted frizzled-related protein (Sfrp-5). Other adipokines have pro-inflammatory impacts on the cardiovascular system and obesity including leptin, tumor necrosis factor (TNF), retinol-binding protein4 (RBP-4), visfatin, resistin, and osteopontin. We found that obesity is associated with multiple CVDs, but can only occur in unhealthy metabolic patients. However, more studies should be designed to clarify the association between obesity, adipokine changes, and the occurrence of CVDs.
Item Type: Article
Uncontrolled Keywords: adipokines; cardiovascular disease; metabolic diseases; obesity
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Milad Ashrafizadeh
Date Deposited: 04 Aug 2023 17:02
Last Modified: 04 Aug 2023 17:02

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