A review on advances in graphene-derivative/polysaccharide bionanocomposites: therapeutics, pharmacogenomics and toxicity

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Makvandi, Pooyan and Ghomi, Matineh and Ashrafizadeh, Milad and Tafazoli, Alireza and Agarwal, Tarun and Delfi, Masoud and Akhtari, Javad and Zare, Ehsan Nazarzade and Padil, Vinod V.T. and Zarrabi, Ali and Pourreza, Nahid and Miltyk, Wojciech and Maiti, Tapas Kumar (2020) A review on advances in graphene-derivative/polysaccharide bionanocomposites: therapeutics, pharmacogenomics and toxicity. Carbohydrate Polymers, 250 . ISSN 0144-8617

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Abstract

Graphene-based bionanocomposites are employed in several ailments, such as cancers and infectious diseases, due to their large surface area (to carry drugs), photothermal properties, and ease of their functionalization (owing to their active groups). Modification of graphene-derivatives with polysaccharides is a promising strategy to decrease their toxicity and improve target ability, which consequently enhances their biotherapeutic efficacy. Herein, functionalization of graphene-based materials with carbohydrate polymers (e.g., chitosan, starch, alginate, hyaluronic acid, and cellulose) are presented. Subsequently, recent advances in graphene nanomaterial/polysaccharide-based bionanocomposites in infection treatment and cancer therapy are comprehensively discussed. Pharmacogenomic and toxicity assessments for these bionanocomposites are also highlighted to provide insight for future optimized and smart investigations and researches.
Item Type: Article
Uncontrolled Keywords: Antimicrobial therapy; Co-delivery; Drug delivery; Graphene oxide nanocomposites; Polysaccharide Bionanocomposites
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 03 Aug 2023 23:55
Last Modified: 03 Aug 2023 23:55
URI: https://research.sabanciuniv.edu/id/eprint/46876

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