Progress in delivery of siRNA-based therapeutics employing nano-vehicles for treatment of prostate cancer

Ashrafizadeh, Milad and Hushmandi, Kiavash and Moghadam, Ebrahim Rahmani and Zarrin, Vahideh and Kashani, Sharareh Hosseinzadeh and Bokaie, Saied and Najafi, Masoud and Tavakol, Shima and Mohammadinejad, Reza and Nabavi, Noushin and Hsieh, Chia Ling and Zarepour, Atefeh and Zare, Ehsan Nazarzadeh and Zarrabi, Ali and Makvandi, Pooyan (2020) Progress in delivery of siRNA-based therapeutics employing nano-vehicles for treatment of prostate cancer. Bioengineering, 7 (3). ISSN 2306-5354

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Prostate cancer (PCa) accounts for a high number of deaths in males with no available curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to the lack of symptoms in the early stages. Recently, the research focus was directed toward gene editing in cancer therapy. Small interfering RNA (siRNA) intervention is considered as a powerful tool for gene silencing (knockdown), enabling the suppression of oncogene factors in cancer. This strategy is applied to the treatment of various cancers including PCa. The siRNA can inhibit proliferation and invasion of PCa cells and is able to promote the anti-tumor activity of chemotherapeutic agents. However, the o_-target e_ects of siRNA therapy remarkably reduce its e_cacy in PCa therapy. To date, various carriers were designed to improve the delivery of siRNA and, among them, nanoparticles are of importance. Nanoparticles enable the targeted delivery of siRNAs and enhance their potential in the downregulation of target genes of interest. Additionally, nanoparticles can provide a platform for the co-delivery of siRNAs and anti-tumor drugs, resulting in decreased growth and migration of PCa cells. The e_cacy, specificity, and delivery of siRNAs are comprehensively discussed in this review to direct further studies toward using siRNAs and their nanoscale-delivery systems in PCa therapy and perhaps other cancer types.
Item Type: Article
Uncontrolled Keywords: Cancer therapy; Delivery systems; Gene therapy; Nanoparticle; Prostate cancer; Small interfering RNA (siRNA)
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 03 Aug 2023 16:05
Last Modified: 03 Aug 2023 16:05

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