STAT3 pathway in gastric cancer: signaling, therapeutic targeting and future prospects

Ashrafizadeh, Milad and Zarrabi, Ali and Orouei, Sima and Zarrin, Vahideh and Moghadam, Ebrahim Rahmani and Zabolian, Amirhossein and Mohammadi, Shima and Hushmandi, Kiavash and Gharehaghajlou, Yashar and Makvandi, Pooyan and Najafi, Masoud and Mohammadinejad, Reza (2020) STAT3 pathway in gastric cancer: signaling, therapeutic targeting and future prospects. Biology, 9 (6). ISSN 2079-7737

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Molecular signaling pathways play a significant role in the regulation of biological mechanisms, and their abnormal expression can provide the conditions for cancer development. The signal transducer and activator of transcription 3 (STAT3) is a key member of the STAT proteins and its oncogene role in cancer has been shown. STAT3 is able to promote the proliferation and invasion of cancer cells and induces chemoresistance. Different downstream targets of STAT3 have been identified in cancer and it has also been shown that microRNA (miR), long non‐coding RNA (lncRNA) and other molecular pathways are able to function as upstream mediators of STAT3 in cancer. In the present review, we focus on the role and regulation of STAT3 in gastric cancer (GC). miRs and lncRNAs are considered as potential upstream mediators of STAT3 and they are able to affect STAT3 expression in exerting their oncogene or onco‐suppressor role in GC cells. Anti‐tumor compounds suppress the STAT3 signaling pathway to restrict the proliferation and malignant behavior of GC cells. Other molecular pathways, such as sirtuin, stathmin and so on, can act as upstream mediators of STAT3 in GC. Notably, the components of the tumor microenvironment that are capable of targeting STAT3 in GC, such as fibroblasts and macrophages, are discussed in this review. Finally, we demonstrate that STAT3 can target oncogene factors to enhance the proliferation and metastasis of GC cells.
Item Type: Article
Uncontrolled Keywords: Cancer therapy; Gastric cancer; Long non‐coding RNA; MicroRNA; Signal transducer and activator of transcription 3 (STAT3); Tumor microenvironment
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 03 Aug 2023 14:57
Last Modified: 03 Aug 2023 14:57

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