Molecular biology of sars-cov-2 [Sars-cov-2'nin moleküler biyolojisi]

Piepoli, Sofia and Shamloo, Bahar and Bircan, Aylin and Adebali, Ogün and Erman, Batu (2020) Molecular biology of sars-cov-2 [Sars-cov-2'nin moleküler biyolojisi]. Turkish Journal of Immunology, 8 (2). pp. 73-88. ISSN 1301-109X

Full text not available from this repository. (Request a copy)


The Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) has resulted in the COVID-19 pandemic, which is currently wreaking havoc in human societies. To understand how this virus causes disease, the molecular biology of the virus needs to be studied in more detail. There is a large body of work on the molecular strategies of previous coronaviruses that infected humans, which can be directly applied to SARS-CoV-2. In the current review we highlight the novel aspects of the SARS-CoV-2 coronavirus life cycle, and how this and other viruses interact with the biochemistry of the host organism. We provide a discussion of different types of viruses as a background to understand coronaviruses. Specifically, we compare the life cycles of coronaviruses with that of a model retrovirus, the Human Immunodeficiency Virus (HIV). We describe the genomic, transcription and translation control features of coronaviruses with a focus on protein structures and activities that can be selected as molecular targets of therapy.
Item Type: Article
Uncontrolled Keywords: Baltimore Classification; Coronavirus; COVID-19; HIV; ORF10; SARS-CoV-2
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Ogün Adebali
Date Deposited: 03 Aug 2023 14:44
Last Modified: 03 Aug 2023 14:44

Actions (login required)

View Item
View Item