In vivo gene delivery mediated by non-viral vectors for cancer therapy

Mohammadinejad, Reza and Dehshahri, Ali and Sagar Madamsetty, Vijay and Zahmatkeshan, Masoumeh and Tavakol, Shima and Makvandi, Pooyan and Khorsandi, Danial and Pardakhty, Abbas and Ashrafizadeh, Milad and Ghasemipour Afshar, Elham and Zarrabi, Ali (2020) In vivo gene delivery mediated by non-viral vectors for cancer therapy. Journal of Controlled Release, 325 . pp. 249-275. ISSN 0168-3659 (Print) 1873-4995 (Online)

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Gene therapy by expression constructs or down-regulation of certain genes has shown great potential for the treatment of various diseases. The wide clinical application of nucleic acid materials dependents on the development of biocompatible gene carriers. There are enormous various compounds widely investigated to be used as non-viral gene carriers including lipids, polymers, carbon materials, and inorganic structures. In this review, we will discuss the recent discoveries on non-viral gene delivery systems. We will also highlight the in vivo gene delivery mediated by non-viral vectors to treat cancer in different tissue and organs including brain, breast, lung, liver, stomach, and prostate. Finally, we will delineate the state-of-the-art and promising perspective of in vivo gene editing using non-viral nano-vectors.
Item Type: Article
Uncontrolled Keywords: Cancer; Clinical translation; Gene delivery; Gene editing; in vivo; Non-viral vectors
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 02 Aug 2023 11:18
Last Modified: 02 Aug 2023 11:18

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