Synthesis, characterization, biological activities and molecular docking of Epilobium parviflorum aqueous extract loaded chitosan nanoparticles

Warning The system is temporarily closed to updates for reporting purpose.

Egil, Abdurrahim Can and Ozdemir, Burak and Gok, Bahar and Kecel-Gunduz, Serda and Budama-Kilinc, Yasemin (2020) Synthesis, characterization, biological activities and molecular docking of Epilobium parviflorum aqueous extract loaded chitosan nanoparticles. International Journal of Biological Macromolecules, 161 . pp. 947-957. ISSN 0141-8130 (Print) 1879-0003 (Online)

Full text not available from this repository. (Request a copy)

Abstract

Epilobium is a medicinal plant; its extracts are widely used traditional medicine due to their broad range of pharmacological and therapeutic properties. Its most prominent feature is its therapeutic effects on prostatic diseases. The aim of this study is preparation of controlled release system of Epilobium parviflorum, and determination of its potential of anticancer applications. For this purpose, Epilobium parviflorum extract (EPE) loaded chitosan nanoparticles were prepared with ionic gelation method to increase the bioavailability of the extract. The nanoparticles were investigated in terms of size, zeta potential, polydispersity index, encapsulation efficiency, loading capacity and release profile. Besides, scanning electron microscopy (SEM) was used to observe the morphology of the nanoparticles. Moreover, Ames/Salmonella test was used to determine the mutagenicity of EPE, and it was shown that it had no mutagenic effect. It was found that EPE loaded chitosan nanoparticles were with 64.47 nm in average size, 0.168 PdI and 15.2 mV zeta potential. Encapsulation efficiency and loading capacity were found as 92.46% and 8%, respectively. Finally, DNA binding assay and in silico molecular docking studies were performed between EPE and DNA in order to contribute to design of plant based controlled release system for use in cancer therapy.
Item Type: Article
Uncontrolled Keywords: Chitosan; DNA binding; Encapsulation; Epilobium parviflorum; Molecular docking; Nanoparticles; Nanotechnology
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Materials Science & Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Abdurrahim Can Egil
Date Deposited: 01 Aug 2023 22:47
Last Modified: 01 Aug 2023 22:47
URI: https://research.sabanciuniv.edu/id/eprint/46760

Actions (login required)

View Item
View Item