Multifunctional polymeric nanoplatforms for brain diseases diagnosis, therapy and theranostics

Shakeri, Shahryar and Ashrafizadeh, Milad and Zarrabi, Ali and Roghanian, Rasoul and Afshar, Elham Ghasemipour and Pardakhty, Abbas and Mohammadinejad, Reza and Kumar, Anuj and Thakur, Vijay Kumar (2020) Multifunctional polymeric nanoplatforms for brain diseases diagnosis, therapy and theranostics. Biomedicines, 8 (1). ISSN 2227-9059

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The blood-brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS) from damage by substances that originate from the blood circulation. The BBB limits drug penetration into the brain and is one of the major clinical obstacles to the treatment of CNS diseases. Nanotechnology-based delivery systems have been tested for overcoming this barrier and releasing related drugs into the brain matrix. In this review, nanoparticles (NPs) from simple to developed delivery systems are discussed for the delivery of a drug to the brain. This review particularly focuses on polymeric nanomaterials that have been used for CNS treatment. Polymeric NPs such as polylactide (PLA), poly (D, L-lactide-co-glycolide) (PLGA), poly (ε-caprolactone) (PCL), poly (alkyl cyanoacrylate) (PACA), human serum albumin (HSA), gelatin, and chitosan are discussed in detail.
Item Type: Article
Uncontrolled Keywords: Central nervous system (CNS); Drug delivery systems; Lood-brain barrier (BBB); Nanotechnology; Polymeric nanoparticles; Theranostics
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 31 Jul 2023 21:11
Last Modified: 31 Jul 2023 21:11

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